P2X4 Receptor Is a Glycosylated Cardiac Receptor Mediating a Positive Inotropic Response to ATP
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چکیده
منابع مشابه
A positive inotropic effect of ATP in the human cardiac atrium.
We studied contractile effects in isolated electrically driven (1 Hz) atrial preparations from patients undergoing cardiac bypass surgery. ATP concentration dependently (10, 30, and 100 microM) and rapidly decreased force of contraction (negative inotropic effect, NIE) and thereafter more slowly increased force of contraction. The maximum positive inotropic effect (PIE) at 100 microM ATP amount...
متن کاملExtracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors.
P2X receptors, activated by extracellular ATP, may be important in regulating cardiac function. The objective of the present study was to characterize the electrophysiologic actions of P2X4 receptors in cardiac myocytes and to determine whether they are involved in mediating the effect of extracellular ATP. Membrane currents under voltage clamp were determined in myocytes from both wild-type (W...
متن کاملCentral P2X4 and P2X6 channel subunits coassemble into a novel heteromeric ATP receptor.
Ionotropic ATP receptors are widely expressed in mammalian CNS. Despite extensive functional characterization of neuronal homomeric P2X receptors in heterologous expression systems, the subunit composition of native central P2X ATP-gated channels remains to be elucidated. P2X4 and P2X6 are major central subunits with highly overlapping mRNA distribution at both regional and cellular levels. Whe...
متن کاملAvailability of cardiac glycosides for pharmacological receptor-site of muscle cells and positive inotropic action.
It is well known that the positive inotropic action of cardiac glycosides occurs in heart muscle cell, while in skeletal muscle cell such action does not appear (1-4). Such discrepant phenomenon would be, of course, related to a general problem on drug-receptor interaction and pharmacological receptor site. A series of experiments was done, therefore, on relationship between action of and intra...
متن کاملA novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor.
The P2X4 receptor is a newly identified receptor expressed in the heart cell. Its function was elucidated with cardiac transgenic (TG) expression of the receptor by using the myocardium-specific a-myosin heavy chain promoter. The presence of the transgene was determined by polymerase chain reaction by using primers specific to the receptor and the vector linker region, by Southern blotting of t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m112097200